Steady-state clonidine plasma levels are obtained within 3 days after transdermal application to the upper outer arm and increase linearly with increasing size of the transdermal patch. Mean steady-state plasma concentrations with the 4.33 cm 2 , 8.67 cm 2 and 13 cm 2 systems are approximately 0.4 ng/mL, 0.8 ng/mL, and 1.1 ng/mL, respectively. Conversion from transdermal to oral: After transdermal patch removal, therapeutic clonidine levels persist for ~8 hours and then slowly decrease over several days. Consider starting oral clonidine no sooner than 8 hours after patch removal. Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily. Clonidine transdermal (skin patch) is used to treat hypertension (high blood pressure). It is sometimes used together Release Rate Concept. Clonidine Transdermal System is programmed to release clonidine at an approximately constant rate for 7 days. The energy for drug release is derived from the concentration gradient existing between the patch and the much lower concentration prevailing in the skin. NON-SENSITIZING TRANSDERMAL CLONIDINE PATCH. RELATED APPLICATIONS. This application claims priority to U.S. provisional application 61/560,577, filed on November 16, 2011, which is hereby incorporated by reference in its entirety. Transdermal clonidine comes as a patch to apply to the skin. It is usually applied to the skin every 7 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. 4 or substitution of oral clonidine hydrochloride therapy may be associated with development of a generalized skin rash. In patients who develop an allergic reaction to CATAPRES-TTS transdermal therapeutic system, Clonidine tablets and transdermal patch Clonidine is used to treat high blood pressure , attention deficit hyperactivity disorder (ADHD), drug withdrawal ( alcohol , opioids , or smoking ), menopausal flushing , diarrhea , and certain pain conditions. In patients who have developed localized contact sensitization to clonidine transdermal system, continuation of clonidine transdermal system or substitution of oral clonidine hydrochloride therapy may be associated with development of a generalized skin rash. How to use Clonidine Patch, Transdermal Weekly. Read the Patient Information Leaflet if available from your pharmacist before you start taking clonidine and each time you get a refill.